Wednesday, May 26, 2010

Lipoprotein

Protein part of lipoprotein is called apo protein.

Types of lipoprotein:
1. Chylomicron
2.VLDL(very low density lipoprotein)
3.LDL
4.HDL

Here one should be noted density will decrease if lipid amount increase.
So in VLDL, lipid is much more than in HDL

another matter;
Increase protein causes the increase elecrophoric mobility.


Basics of apoprotein:
maintenance the shape of liupoprotein.
B100. the apoprotein which synthesize by B gene 100%
B48... B gene synthesize 48% of the protein.


metabolism of Lipoprotein:

Chylomicron:
Site of synthesis: Small intestine.
Size 100 nano m
Low density
combines with C1,11,111 E in circulation.

lipid 98-99%
Protein 1%

Functions:
Transport dietary TG,Cholesterol,Cholesterol Ester from instestine to peripheral
tissue.

Metabolism:
Extrahepatic tissue by lipoprotein lipase.

Metabolic end product:
FFA
Glycerol
Chylomicron remnant(Removed by liver )

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