Metabolism of TG/Triacyl glycerol

TG is consit of three molecule of fatty acid esterified into glycerol.

Storage:

Main storage: Adipose cell. Most of TG deposite as droplet.
Other store: Liver and muscle cell, Store small amount of TG.

Fate of TG:

1. Fate of Adipose tissue TG:
Store in cytosol as depot fat.
Ready to mobilize when body require fuel.
2. Liver: TG is packed with cholesterol, Cholesterol ester
Phospholopid ,protein forms various lipoprotein.

Biosynthesis:
Site : liver and adipose tissue.

Source : FFA.(free fatty acid)

Lipolysis of TG:

hydrolysis of TG is called lipolysis.

Enzyme required:
Lipase.
a. In adipose tissue: Hormone sensitive lipase.
b. In vessles. Lipoprotein lipase(chylomicron, VLDL)

hormone sensitive lipase
TG......................................................>>>DAG(diacylglycerol)+FFA


DAG....................................................>>>MAG+FFA

MAG..................................................>>>Glycerol+FFA

So the products of lipolysis are:
a. FFA
b.Glycerol

Fate of Glycerol:
a.In adipose tisssue..Can not utilize glycerol as there is no enzyme to metabolise
So glycerol is the excellent index of glycolysis in adipose tissue.
b.In liver. glycerol is converted to glycerol phosphate by glycerol kinase.